Unit - I Controlled drug delivery systems : Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations Polymers : Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery systems. (Chapters - 1, 2) Unit - II Microencapsulation : Definition, advantages and disadvantages, microspheres / microcapsules, microparticles, methods of microencapsulation, applications Mucosal Drug Delivery system : Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems Implantable Drug Delivery Systems : Introduction, advantages and disadvantages, concept of implants and osmotic pump. (Chapters - 3, 4, 5) Unit - III Transdermal Drug Delivery Systems : Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches Gastroretentive drug delivery systems : Introduction, advantages, disadvantages, approaches for GRDDS - Floating, high density systems, inflatable and gastroadhesive systems and their applications Nasopulmonary drug delivery system : Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers (Chapters - 6, 7, 8) Unit - IV Targeted drug Delivery : Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications (Chapter - 9) Unit - V Ocular Drug Delivery Systems :
