Unit I Basic principles of cell injury and adaptation: Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury, Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage), Morphology of cell injury - Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia), Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis and Alkalosis, Electrolyte imbalance (Chapter - 1) Basic mechanism involved in the process of inflammation and repair: Introduction, Clinical signs of inflammation, Different types of Inflammation, Mechanism of Inflammation - Alteration in vascular permeability and blood flow, migration of WBC’s, Mediators of inflammation, Basic principles of wound healing in the skin, Pathophysiology of Atherosclerosis (Chapter - 2) Unit II Cardiovascular system: Hypertension, congestive heart failure, ischemic heart disease (angina, myocardial infarction, atherosclerosis and arteriosclerosis) (Chapter - 3) Respiratory system: Asthma, Chronic obstructive airways diseases. (Chapter - 4) Renal system: Acute and chronic renal failure. (Chapter - 5) Unit II Haematological diseases: Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia. (Chapter - 6) Endocrine system: Diabetes, thyroid diseases, disorders of sex hormones (Chapter - 7) Nervous system: Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease. (Chapter - 8) Gastrointestinal system: Peptic Ulcer (Chapter - 9) Unit IV Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease. (Chapter - 10) Disease of bones and joints: Rheumatoid arthritis, osteoporosis and gout (Chapter - 11) Principles of cancer: classification, etiology and pathogenesis of cancer (Chapter - 12) Unit V Infectious diseases : Meningitis,Typhoid, Leprosy, Tuberculosis Urinary tract infections (Chapter - 13) Sexually transmitted diseases : AIDS, Syphilis, Gonorrhea (Chapter - 14)
